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Metabolic engineering is a new field with applications in the production of chemicals, fuels, materials, pharmaceuticals, and medicine at the genetic level. The field's novelty is in the synthesis of molecular biology techniques and the tools of mathematical analysis, which allow rational selection of targets for genetic modification through measurements and control of metabolic fluxes. The objective is to identify specific genetics or environmental manipulations that result in improvements in yield and productivities of biotechnological processes.
Key features of the book are pathway integration and the focus on metabolic flux as a fundamental determinant of cell physiology. The book keeps mathematical complexity to a minimum, and provides a glossary of biological terms to facilitate use of the book by a broader spectrum of readers. A web page exists to communicate updates of the codes and homework problems.


Key Features
* Demonstrates metabolic engineering in action with numerous examples of pathway modification
* Includes methods for identifying key enzymes in metabolic networks
* Contains a comprehensive review of metabolic biochemistry
* Discusses metabolic regulation at the gene, enzyme, operon, and cell levels
* Explains concepts of stoichiometry, kinetics, and thermodynamics of metabolic pathways
* Minimizes mathematical complexity
* Links to a Web page to communicate updates of the software code and homework problems

• Sales Rank: #1007158 in Books
• Published on: 1998-10-16
• Original language: English
• Number of items: 1
• Dimensions: 9.02" h x 1.56" w x 5.98" l, 2.49 pounds
• Binding: Hardcover
• 725 pages

From the Back Cover
Metabolic engineering is an emerging, interdisciplinary field with applications to the production of chemicals, fuels, materials, and pharmaceuticals. The field's novelty lies in the integration of the techniques of molecular biology with the tools of mathematical analysis, to help elucidate metabolic flux control and rational selection of targets for genetic modification. By providing a rigorous description of cell physiology, metabolic engineering also facilitates functional genomics. Its primary objective is to identify specific genetic and environmental manipulations that lead to enhancement of yield and productivity of biotechnological processes, or the overall improvement of cellular properties.
Key elements of the book include pathway integration and consideration of metabolic flux as a fundamental determinant of cell physiology. Metabolic Engineering keeps mathematical complexity to a minimum ,and provides sidebars as additional background on various mathematical operations. Computational tools for pathway analysis are described, and a glossary of biological terms facilitates use of the book by a broad audience of biochemists, molecular biologists, microbiologists, and biochemical/biomedical engineers.

About the Author
Gregory Stephanopoulos is a Professor of Chemical Engineering at MIT. He received his B.S. from the National Technical University of Athens, his M.S. from the University of Florida and his Ph.D. from the University of Minnesota, all in Chemical Engineering. Upon graduation, he joined the Chemical Engineering Faculty of the California Institute of Technology, where he served as Assistant and Associate Professor until 1985. In 1985 he was appointed Professor of Chemical Engineering at MIT where he has been ever since.Stephanopoulos' work has appeared in more than 150 publications and 7 patents. He has been recognized with the Dreyfus Foundation Teacher Scholar Award (1982), Excellence in Teaching Award (1984), and Technical Achievement Award of the AIChE (1984). He has been a Presidential Young Investigator and the Chairman of the Food Pharmaceutical & Bioengineering Division of the American Institute of Chemical Engineers (1992). In 1992 he was a Visiting Professor at the International Research Center for Biotechnology at Osaka University and was elected a Founding Fellow of the American Institute for Medical and Biological Engineering. In 1996 he chaired the first Conference on Metabolic Engineering and gave the inaugural Bayer Lecture on Biochemical Engineering at the University of California at Berkeley. He was honored with the FPBE Division Award at AIChE in 1997.

Most helpful customer reviews

6 of 6 people found the following review helpful.
Excellent
By Marshall
This book was a very pleasant surprise. It is rigurous yet accessible enough to provide a very clear picture of the metabolic pathway engineering field. Complicated topics like metabolic control and flux analisys (MCA) are very well treated. The examples are usually relevant and well explained, however, some need pen and paper to work up some jumps in the reasoning train. The first chapter is just an introduction whereas the second chapter is a review of cellular metabolism that may result too dense for most people (including myself). Most biologists can probably do away skipping it (althought some examples involving transport where quite interesting). I am glad I didn't put the book away because on chapter 3 things get really exciting. If you are interested in understanding how metabolic pathways are organized and what analytical tools are there available to model them (and eventually "reconfigure") this book for you.

Note: the book is meatn to be undestood and it is nice to see MCA depleted of the hoopla many authors insist on surrounding it with.

0 of 0 people found the following review helpful.
Deep and didactic
By Bernardo A A Gradin
The book is a must for those who wish to understand the power of biotechnology to change the world. All the fundamental concepts are explained in depth with a very didactic approach.

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o Debrett's first book defining all aspects of life for the modern man

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• Sales Rank: #1064488 in Books
• Brand: Brand: Antique Collectors Club Dist
• Published on: 2009-07-16
• Original language: English
• Number of items: 1
• Dimensions: 10.06" h x .87" w x 8.04" l, 1.60 pounds
• Binding: Hardcover
• 192 pages

Features

• Used Book in Good Condition

Most helpful customer reviews

14 of 16 people found the following review helpful.
Handy and Hilarious
By Shirley A. Dornbirer
I just love this book. It covers basically anything you've ever had a question about. Back hair, Sex, the proper blazer length, how to break off a date, cologne, and tons more. If you want to brush up on your manners this is the book for you. It's a pleasure to read, with loads of illustrations and diagrams. The authors are unapologetic and blunt, with just the right amount of witty humor.

1 of 1 people found the following review helpful.
Fun
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10 of 13 people found the following review helpful.
Simply dreadful
By Mark Hollingsworth
What a dreadful book. I'm amazed that such a prestigious organization as Debretts would publish such a lightweight book. If this is how a modern gentleman is expected to live then, that the age of 52, I think I'm going to have go back into my cave as a traditionalist!

To give you some examples of the useless trivia in this book here are a few areas: The section on office meetings tells you to "be punctual". Really?; There is a section dedicated to the martial arts, hardly the sport of a gentleman; How to act in a VIP area of a bar - I'm not sure a gentleman would ever wish to be seen in such modern salubrious places; How to wear flip-flops! - no self-respecting gentleman would ever be seen wearing flip-flops; How to climb Mount Everest! - how tacky; When flying "never try to chat up the stewardess" - oh dear. I could go on, but I think you probably get the idea.

Yes there are some interesting sections in the book on purchasing, owning and caring for, and wearing clothing appropriate to the style of a gentleman. There are some sections on etiquette in restaurants, bars, hotels, etc. But this form of etiquette has not changed for many many years, and in fact Debrett's guide to etiquette from the early 80s is still fairly applicable today.

This book is so lightweight, and so inappropriate to the traditional gentlemen, that it could actually just float away, and never be seen again. The world would be a better place if that happened.

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• Sales Rank: #1993648 in Books
• Published on: 2013-04-16
• Original language: English
• Dimensions: 9.00" h x .13" w x 6.00" l,
• Binding: Paperback
• 56 pages

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• Published on: 2014-05-20
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• Sales Rank: #7922344 in Books
• Published on: 2014-11-20
• Original language: English
• Number of items: 1
• Dimensions: 7.80" h x .94" w x 5.12" l, .66 pounds
• Binding: Paperback

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55 of 59 people found the following review helpful.
Just Didn't Work for Me
By D. Miles
If I didn't know better I would swear two different authors wrote this book. The sections set in current times were boring and I really didn't like any of the characters. I love Russian history so decided to skip to the fairytale parts of the book and low and behold here was a really good story! The writing styles were so different...why couldn't the entire book be written this way? I just skimmed through the parts in current times. And I'm sorry, the idea that because the mother suffered so much in Russia gave her the excuse to emotionally abuse her daughters and the supposedly loving father allowed it to go on just didn't work for me. If you want to read an incredible love story set during World War II and the siege of Leningrad...read The Bronze Horseman Trilogy by Paulina Simons. These books will simply sweep you off your feet and break your heart...incredible story written by a Russian who lived in Soviet Russia and whose grandparents lived through the siege. On my list of all time favorites!

0 of 0 people found the following review helpful.
It could have been better
By Robert Specking
I stayed with this book, even though it was frustrating, hoping it would get better. It did, but it would have been much better if it only would have contained the story in Russia. The first half was slow and the main characters very unlikable. The character flaws were overblown and the men too good to be true.
The Russian story is much more believe able and told in a way that made the reader feel the cold and hunger. I thought the end would be rewarding because of the style change but after Anya finishes her story the author goes back to the same trite style. Everything wraps up neatly, characters are brought together, and after 40 years of coldness and dysfunction everyone loves each other. It starts as a fairy tale and ends a fairy tale.

0 of 0 people found the following review helpful.
I think Kristin Hannah is a great author and storyteller
By Tiffany
I think Kristin Hannah is a great author and storyteller. I have enjoyed many of her books. This one is no exception, it is a great story, but it is a sad story. The only negative I can find is that at times the character development can drag on. I think that I am kind of impatient when it comes to that style of writing so I find myself skimming a bit. Others I know love in depth character development, but for me personally, I love a good balance between character and story. I would recommend this book to anyone who has an interest in history, especially WW2 history. I would recommend any of Kristin Hannah's books if you enjoy stories about families who are less than perfect.

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• Sales Rank: #3445760 in Books
• Published on: 2008
• Binding: Imitation Leather
• 2368 pages

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0 of 0 people found the following review helpful.
Five Stars
By Candise Schmidt
Great Bible. Awesome commentary and notes. Great price.

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• Sales Rank: #9802760 in Books
• Published on: 2012
• Binding: Paperback

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• Sales Rank: #3507665 in Books
• Published on: 2015-06-16
• Format: Large Print
• Original language: English
• Number of items: 1
• Dimensions: 9.00" h x .8" w x 6.00" l, .15 pounds
• Binding: Paperback
• 30 pages

About the Author
As a child, Amy Beard dreamed of being an astronaut. Since graduating high school, however, Amy has held many different jobs - jobs she had no idea existed. From candy making to studying salmon, from electronic manufacturing to the steel industry - Amy has learned that there are as many jobs in the world as there are dreams.

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By William P. Beard
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The riveting true story of the women who launched America into space.

In the 1940s and 50s, when the newly minted Jet Propulsion Laboratory needed quick-thinking mathematicians to calculate velocities and plot trajectories, they didn't turn to male graduates. Rather, they recruited an elite group of young women who, with only pencil, paper, and mathematical prowess, transformed rocket design, helped bring about the first American satellites, and made the exploration of the solar system possible.

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• Sales Rank: #5050 in Books
• Published on: 2016-04-05
• Released on: 2016-04-05
• Original language: English
• Number of items: 1
• Dimensions: 9.63" h x 1.25" w x 6.38" l, .0 pounds
• Binding: Hardcover
• 352 pages

Amazon.com Review
An Amazon Best Book of April 2016: Women's history buffs rejoice! Wonderfully told and intrinsically captivating, this is the story about the elite group of women in the 40s and 50s who broke gender and science boundaries to transform rocket design and lay the groundwork for U.S. space travel. Not only did I geek out on the incredible look into the early days of the Jet Propulsion Laboratory, but I also fell in love with these women who quite possibly invented the pant suit, and were vital to America's space travel. --Penny Mann

Review
A New York Times bestseller
An Amazon Best Book of April 2016
An Entertainment Weekly "10 Books You Have to Read in April"
An Elle "8 Books by Women for Bill Gates to Read This Summer"


"Holt's accessible and heartfelt narrative celebrates the women whose crucial roles in American space science often go unrecognized."―Publishers Weekly, Starred Review

"Wow! Talk about forgotten history! Those interested in space history will find much to enjoy here, but it is the stories of the women involved, highlighted in sections by decade, that commands attention....and her stellar research is evident on every page. This is an excellent contribution to American history, valuable not only for what it reveals about the space program and gender equality but even more as great reading. Book clubs will be lining up."
―Colleen Mondor, Booklist (Starred Review)

"Engaging history....a fresh contribution to women's history."
―Kirkus

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―Gene Seymour, USA Today (3.5 stars/4)


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―Cate Lineberry, author of The Secret Rescue: An Untold Story of American Nurses and Medics Behind Nazi Lines

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―TaraShea Nesbit, bestselling author of The Wives of Los Alamos

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―Martha Ackmann, author of The Mercury 13: The True Story of Thirteen Women and the Dream of Space Flight

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―Dr. Charles Elachi, Director of the Jet Propulsion Laboratory, Vice President of the California Institute of Technology, and Professor of Electrical Engineering and Planetary Science

"Holt gives voice to the seldom-recognized female mathematicians and scientists who shaped NASA in its earliest years and beyond."―ALA Magazine

"Non-fiction tends to be a good reading slump buster for me, and this one seems perfect."
―Andi Miller, Book Riot

"Holt seamlessly blends the technical aspects of rocket science and mathematics with an engaging narrative, making for an imminently readable and well-researched work."―Crystal Goldman, Library Journal (Starred Review, Editors' Choice Pick)

"Most of our time in history class is spent learning about men, but women were obviously just as vital to innovation and progress. Rise of the Rocket Girls proves that by reexamining the space age--specifically, the group of women who redesigned rocket science...and made that 'one small step for man' possible in the first place."
―Isabella Biedenharn, Christian Holub, Dana Getz, Entertainment Weekly

"Here, math is dramatic, not mundane. Calculating is a physical, even athletic, act....Personal anecdotes...will fascinate general readers and provide valuable primary source materials for future academics."―Jennifer Light, Nature

"Holt does a fine job balancing the personal stories of these women with the technical discussions of their work ....Rise of the Rocket Girls tells a fascinating story of the women who made largely unseen yet essential contributions to the early history of spaceflight."
―Jeff Foust, The Space Review


"These female pioneers who helped the U.S. win the space race are finally getting their due....The book acts as a fascinating time capsule, capturing what it was like to be a working woman at a time when only 20 percent of women worked outside the home, or when a woman could be fired simply for being pregnant."
―Naomi Shavin, Smithosonian

"The women's stories are fun, intense, and endearing, and they give a new perspective on the rise of the space age."―Popular Science


"Marvelous....Thoroughly wonderful....Nathalia Holt reclaims the role of these unheralded women scientists in the field that has enchanted humanity's collective imagination more powerfully than any other: space exploration....Their untold story illuminates the broader cultural context of changes that are still ripening today."―Maria Popova, Brain Pickings


"Holt deserves credit for bringing this story to light....she is able to offer a backstage view of the bumpy start of the Space Age."―Julia M. Klein, Boston Globe


"A must read for any women in tech or interested in technology!"―Girls Who Code


"We hope the renewed history of the rocket girls continues to inspire more girls and women to pursue STEM fields so the gender gap is sealed once and for all."
―Makers

"Holt's book shines portraying the mathematical and engineering process behind JPL's many iconic spaceflight missions--including America's first satellite, Explorer 1, and the Voyager probes that explored the solar system--as well as the women's personal lives and the evolution of their unusual roles inside the male-dominated workplace."
―Space.com

"Holt investigates the fascinating lives and important contributions of these women, who defied the sexist stereotypes of their times to play pivotal roles in sending the first rockets beyond Earth."―Scientific American

"Nathalia Holt's Rise of the Rocket Girls is an immersive, evocative narrative that effectively brings an all-too-forgotten history to life.... Deeply researched... skillfully written... superbly readable.... Holt's poignant narrative should be required reading for anyone who studies aeronautics, history or women's rights."
―Maya Gittelman, Bookreporter

"An intriguing account of the young, female 'human computers' who worked at Caltech's Jet Propulsion Laboratory. Be inspired by their work on America's first satellite and other groundbreaking projects, against the social backdrop of the Space Age, slowly changing gender norms, and the dawn of computers."―Estelle Tang, Elle, "5 Books That You Can Read With Your Mom"


"Rocket science has long been associated with men...but in Rise of the Rocket Girls, Nathalia Holt shines a light on the women behind the scenes."
―Eliza Thompson, Cosmopolitan, "6 New Books to Read This Month"


"Inspiring and thought-provoking, this book will change the way you look at the history of space travel--as well as its future."―Katherine Handcock, A Mighty Girl, "25 New Mighty Girl Books for Early Spring"


"Incredible....Holt unveils this forgotten history with nuance and insight."
―Laurel Raymond, Think Progress

About the Author
Nathalia Holt is the author of Cured: The People Who Defeated HIV and a former Fellow at the Ragon Institute of Massachusetts General Hospital, MIT, and Harvard University. Her writing has appeared in the New York Times, the Los Angeles Times, The Atlantic, Slate, Popular Science, and Time. She lives in Boston.

Most helpful customer reviews

46 of 48 people found the following review helpful.
Buy this book! A fantastic history of the women who pioneered space flight!
By Antonio Paola
I have read this book twice already. I honestly loved it in so many ways. It's one of those rare, well-written, well-researched books that serves as a great tribute to these women; a tribute to the women pioneers of space flight. Nathalia, thank you for sharing their story!

19 of 21 people found the following review helpful.
Fascinating subject, mediocre book
By Jeff C*
The story of the rocket girls (first women "engineers" at JPL) is definitely worth telling, unfortunately the author wrote a pretty amateurish book about them that is both disorganized and lacking in cohesive flow. Far too many sentences (perhaps 25% in some chapters) in the boook start with "Despite, Although, or While", making the process of reading the book laborious and a bit of a chore at times. Also, every chapter seems to have dozens of random sentences that introduce a new point or topic out of no where, and goes no where with it.

6 of 6 people found the following review helpful.
Human aspect was interesting but factual info was NOT
By SLK
While the story about the women was interesting, there were a LOT of incorrect information about the rockets, computer (the machine ones, not the women) and space items. The author should have spent more time with her research of the technical aspects or just didn't have correct data sources.

See all 183 customer reviews...

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